Endocrine Abstracts

Several reports of Graves’ disease (GD) onset after COVID-19 vaccination were recently published. The mechanism underlying GD occurrence in these cases could be related to the autoimmune syndrome induced by adjuvants (ASIA), a condition triggered by several vaccine adjuvants and excipients leading to dysfunctional immune response causing different conditions and endocrinopathies in genetically predisposed subjects. In Italy, population campaign for COVID-19 vaccination st...

Medullary thyroid cancer (MTC) is a rare malignancy of the thyroid gland. MTCs originate from thyroid-C cells and account for 2-4% of all thyroid neoplasms. Originating from thyroid-C cells, the main secretory product of MTCs is calcitonin, used as sensitive and specific MTC-biomarker. Calcitonin is a hormone known to participate in calcium-bone metabolism suppressing bone-resorption by inhibiting the activity of osteoclasts, and inhibiting the kidney reabsorption of calcium a...

Hypocalcemia has been recently identified as a major biochemical distinctive feature of COVID-19, predicting poor clinical outcomes. Besides the calcium-dependent viral mechanisms of action and the enhanced cellular permeability to calcium ions, we previously hypothesized that hypovitaminosis-D could be a predisposing factor to hypocalcemia. Actually, high prevalence of vitamin D (VD) deficiency in COVID-19 patients (pts) was reported by several studies, but, to date, only few...